姓名：張淑芸 職稱：教授
主要學習與工作經曆：
1996年9月-2000年7月：上海交通大學，本科
2002年4月-2008年3月：日本名古屋大學，碩士、博士
2009年6月-2013年6月：美國國立衛生研究院(NIH)，博士後
2013年6月-2023年6月：溫州醫科大學，研究員 博士生導師
2023年6月-至今：伟德首页官网 教授
主要學術成果與榮譽：
主持國家級、省部級等科研項目多項，培養多名省級和校級優秀碩士研究生，指導多篇省級和校級優秀碩士學位論文，多次榮獲省級和校級優秀碩士學位論文指導教師稱号。
主要研究方向：
環境毒理學、代謝性疾病的調控機制
代表性科研論文（第一作者或通訊作者）：
(1). Zhang SY, Gan X, Shen B, Jiang J, Shen H, Lei Y, Liang Q, Bai C, Huang C, Wu W, Guo Y, Song Y, Chen J. 6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish. Journal of Hazardous Materials, 455: 131601, 2023
(2). Zhang SY, Lei YH, Liang Q, Wang Y, Zheng Y, Gan X, Bai C, Chen J. Cold stress during the perinatal period leads to developmental and neurobehavioral toxicity in zebrafish larvae. Neurotoxicology and Teratology, 96:107164, 2023
(3). Shi Z, Li X, Zhang YM, Zhou YY, Gan XF, Fan QY, He CQ, Shi T, Zhang SY. Constitutive androstane receptor (CAR) mediates pyrene-induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells. British Journal of Pharmacology, 179(23):5209-5221, 2022
(4). Tao LP, Li X, Zhao MZ, Shi JR, Ji SQ, Jiang WY, Liang QJ, Lei YH, Zhou YY, Cheng R, Shi Z, Deng W, Zhu J, Zhang SY. Chrysene, a four-ring polycyclic aromatic hydrocarbon, induces hepatotoxicity in mice by activation of the aryl hydrocarbon receptor (AhR). Chemosphere, 276, 130108, 2021
(5). Yang H, Shi Z, Wang XX, Cheng R, Lu M, Zhu J, Deng W, Zeng Y, Zhao LY, Zhang SY. Phenanthrene, but not its isomer anthracene, effectively activates both human and mouse nuclear receptor constitutive androstane receptor (CAR) and induces hepatotoxicity in mice. Toxicology and Applied Pharmacology, 378:114618, 2019
(6). Zhu J, Zhao LY, Wang XX, Shi Z, Zhang Y, Wu G, Zhang SY. Identification of Hepatotoxicity and Renal Dysfunction of Pyrene in Adult Male Rats. Environmental Toxicology, 33:1304–1311, 2018
(7). Zhao LY, Xu JY, Shi Z, Englert NA, and Zhang SY. Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression. Biochemical Pharmacology, 142:194-203，2017
(8). Xu JY, Wu L, Shi Z, Zhang XJ, Englert NA, Zhang SY. Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25. Environmental Toxicology, 32(3):970-978, 2017
(9). Zhang XJ, Shi Z, Lyv JX, He X, Englert NA, Zhang SY. Pyrene is a novel constitutive androstane receptor (CAR) activator and causes hepatotoxicity by CAR. Toxicological Sciences, 147(2):436-445, 2015
(10). Shi Z, Yang W, Goldstein JA, Zhang SY. Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression. Biochemical Pharmacology, 90(4):425-431, 2014
(11). Zhang SY, Surapureddi S, Coulter S, Ferguson S, and Goldstein JA. Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Molecular Pharmacology, 82(3):529-540, 2012
(12). Zhang SY, Ueyama J, Ito U, Yanagiba Y, Okamura A, Kamijima M and Nakajima T. Permethrin may induce adult male mouse reproductive toxicity due to cis isomer not trans isomer. Toxicology, 248 (2-3):136-141, 2008
(13). Zhang SY, Ito Y, Yamanoshita O, Yanagiba Y, Kobayashi M, Taya K, Li C, Okamura A, Miyata M, Ueyama J, Lee CH, Kamijima M, and Nakajima T. Permethrin May Disrupt Testosterone Biosynthesis via Mitochondrial Membrane Damage of Leydig Cells in Adult Male Mouse. Endocrinology, 148 (8):3941-3949, 2007
主持的科研項目：
國家自然科學基金 (31500946、31871197)、浙江省自然科學基金(2017C33128、LY21H260003)、浙江省醫藥衛生科技計劃項目(2016KYA134、2020KY630)等。
聯系方式：
地址：浙江省台州市市府大道1139号 伟德首页官网
Email：shuyunzh@tzc.edu.cn
