師資隊伍

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醫學基礎部

曹軒

 

全面主持學院行政工作。主管學院發展規劃、學科建設、教學基層組織建設、人才引進、财務管理等。聯系附屬醫院及臨床伟德首页官网。

曹軒,教授、博導,伟德首页官网院長

 

 

主要學習與工作經曆:

1996.9-2000.6 湖南師範大學生命科學學院,本科,學士

2003.9-2008.6 武漢大學生命科學學院,碩博連讀,博士

2008.10-2013.10 加拿大Western University伟德首页官网,博士後

2013.10-2015.3 加拿大Western University伟德首页官网,副研究員

2015.3-2020.8 華中科技大學同濟基礎伟德首页官网,教授、博導,支部書記

2020.8-2023.2 華中科技大學同濟基礎伟德首页官网,教授、博導,副院長

2023.2-至今: 伟德首页官网,教授、碩導、學科領軍人才,院長

主要科研成果、榮譽與學術任職:

以第一或通訊作者Nature CommunicationsPNASTheranosticsBiosensors & bioelectronics, JECCR, Clinical and translational medicine, Cell death & diseaseAnalytica chimica actaFASEB J等國際知名刊物發表十餘篇研究論文,獲中國發明專利4項、PCT國際發明專利1項。主持國家自然科學基金面上項目4項(2015、2017、2019、2024)、湖北省傑出青年基金1項、武漢科技晨光計劃1項。2016年入選湖北省委組織部百人計劃,2016年獲湖北省科技進步獎三等獎,2019年入選華中科技大學華中卓越學者,2022年獲湖北省教學成果獎二等獎。浙江省生物醫學學會理事。《醫藥導報》編委。台州市博士聯誼會常務理事。

主要研究方向:

1.癌症、糖尿病、心血管疾病等慢性疾病的發生發展分子機制研究與新型靶向藥物研發。

2.中藥活性成分抗癌、糖尿病、心血管疾病等慢性疾病的作用分子機制研究。

3.環境分子醫學與環境分子毒理學。

主要研究論文(第一作者或通訊作者):

2024年度: 

Yazhou Sang#, Yue Hu#, Yueyue Zhang, Luyi Chen, Yutian Lu, Lin Gao, Yunyun Lu, Xuan Cao曹軒*, Yaqiong Zhang , Guofu Chen“Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.” Journal of Ethnopharmacology 2025, 338(Pt 2):119071. Epub 2024 Nov 9(IF:4.8,中科院小類一區top期刊

Ya Zhu, Lan Li, Shaokui Yi, Rui Hu, Jianjun Wu, Jinqian Xu, Junguang Xu, Qinnan Zhu, Shijia Cen, Yuxuan Yuan, Da Sun, Waqas Ahmad, Huilan Zhang, Xuan Cao曹軒*,  Jingjuan Ju“Deep learning-assisted detection of psychoactive water pollutants using behavioral profiling of zebrafish embryos” Journal of Hazardous Materials 2024, 480:136358.(IF:12.2,中科院一區top期刊

Guoqing Hou, Weihua Hu, Yazhou Sang, Xiaocai Gan, Hui Xu, Qiongying Hu, Xuan Cao曹軒* “Corynoxine Triggers Cell Death Via Activating PP2A and Regulating AKT-mTOR /GSK3β Axes in NSCLC” Biochem Pharmacol 2024, 222:116110(IF:5.3,中科院二區,藥理學國際知名期刊

        2023年度:

Hui Xu#, Ming Tan#, Guo-Qing Hou, Ya-Zhou Sang, Li Lin, Xiao-Cai Gan, Xuan Cao曹軒*, An-Dong Liu* Blockade of DDR1/PYK2/ERK signaling suggesting SH2 superbinder as a novel autophagy inhibitor for pancreatic cancer Cell Death Disease 2023, 14(12): 811 (IF: 9中科院一區top期刊)

Feng Liu# , Qian Zhou#, Hai-Feng Jiang#, Ting-Ting Zhang, Cheng Miao, Xiao-Hong Xu, Jia-Xing Wu, Song-Lin Yin, Shi-Jie Xu, Jing-Yi Peng, Pan-Pan Gao, Xuan Cao曹軒*, Feng Pan*, Ximiao He*, Xiao Qian Chen* Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity J Exp Clin Cancer Res 2023 42(1):118 (IF: 11.3中科院一區top期刊)

     2015-2022年:

Meng Wang, An-Dong Liu, Qian Niu, Shawn Shun-Cheng Li, Wan-Li Ma*,Xuan Cao曹軒*, Hong Ye*“Blockade of Phosphotyrosine Pathways Suggesting SH2 Superbinder as a Novel Therapy for Pulmonary Fibrosis” THERANOSTICS 2022 1210):4513-4535(IF:12.4中科院一區top期刊)

Xi Zhang, Hui Xu, Xiaoyang Bi, Guoqing Hou, Andong Liu,Youyun Zhao,Guoping Wang*,Xuan Cao曹軒*“Src acts as thetargetof matrineto inhibitthe proliferation of cancercells by regulatingphosphorylation signaling pathways”CELL DEATH DIS 2021 12:931 (IF:9中科院一區top期刊)

Lin Xu, Xinge Zhang, Yue Xin, Jie Ma, Chenyan Yang, Xi Zhang, Guoqing Hou, X Charlie Dong, Zhaoli Sun, Xiwen Xiong*,Xuan Cao曹軒*“Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of    PPARα pathway” CELL DEATH DIS 2021 12:710 (IF: 9中科院一區top期刊)

An-Dong Liu#, Jie Zhou#, Xiao-Yang Bi, Guo-Qing Hou, Shawn Shun-Cheng Li, Qing Chen, Hui Xu,Xuan Cao曹軒*Aptamer-SH2 Superbinder based targeted therapy for Pancreatic ductal adenocarcinoma”CLIN TRANSL MED 2021 11e337(IF:10.6中科院一區期刊)

Jie Deng,Chunmei Wen,Xiangyu Ding,Xi Zhang,Guoqing Hou,Andong Liu,Hui Xu,Xuan Cao曹軒*,Yongheng Bai*,“LKB1-MARK2signalling mediates lipopolysaccharide-induced production of cytokines in mouse macrophages”J Cell Mol Med 2020 24(19):11307-11317 (IF:5.3中科院二區top期刊)

Xi Zhang, Guoqing Hou, Andong Liu, Hui Xu, Yang Guan,Yaosong Wu, Jie Deng,Xuan Cao曹軒*,“Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways.”

CELL DEATH DIS2019 10(10):770 (IF: 9中科院一區top期刊)

Jie Deng#, An-Dong Liu#,Guo-Qing Hou,Xi Zhang,Kun Ren,Xuan-Zuo Chen, ShawnS.C.Li,Yao-SongWu,Xuan Cao曹軒*, "N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling. "J EXP CLIN CANC RES2019 38:2 (IF: 11.3中科院一區top期刊)

Wenjiao Li, Ning Li, Shiyu Dai, Guoqing Hou, Kanglin Guo, Xuanzuo Chen, Changhua Yi, Weiyong Liu, Fei Deng, Yaosong Wu*,Xuan Cao曹軒*,“Zika virus circumvents host innate immunity by targeting the adaptor protein MAVS and MITA.”FASEB Journal 2019 33(9):9929-9944(IF:4.8中科院二區top期刊)

Ai-Qing Ke, An-Dong Liu, Ya-Nan Gao, Dan-Ni Luo, Zhao-Feng Li, Yue-Qi Yu, Jia-Ying Liu, Hui Xu*,Xuan Cao曹軒*, "Development of novel affinity reagents for detecting protein tyrosine phosphorylation based on superbinder SH2 domain in tumor cells. "ANAL CHIM ACTA2018 1032138-146 (IF: 6.2中科院小類一區top期刊)

An-dong Liu, Hui Xu, Ya-nan Gao,Dan-ni Luo,Zhao-fengLi,Courtney Voss, Shawn S.C. Li,Xuan Cao曹軒*, "(Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling. "J EXP CLIN CANC RES 2018 37(1):138 (IF: 11.3中科院一區top期刊)

Cao X曹軒,Kaneko T, Li JS, Liu AD, Voss C, Li SS.,“A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.”NAT COMMUN 2015 6:7721IF: 16.6中科院一區top期刊)

2015年之前

Cao X曹軒,Voss C, Zhao B, Kaneko T, Li SS.,“Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation.”P NATL ACAD SCI USA2012 109(5)1455-60. (IF: 11.1中科院一區top期刊)

Cao X曹軒,Wang YF, Zhang CF, Gao WJ., “Visual DNA microarrays for simultaneous detection of Ureaplasma urealyticum and Chlamydia trachomatis coupled with multiplex asymmetrical PCR.”, Biosens Bioelectron.2006 22(3):393-8. (IF12.6中科院一區top期刊)

發明專利:

中國發明專利:

快速檢測沙眼衣原體的熒光定量PCR試劑盒(第一發明人)

快速檢測細小脲原體的熒光定量PCR試劑盒(第一發明人)

同步檢測沙眼衣原體和細小脲原體的熒光定量PCR試劑盒(第二發明人)

一種突變的IRS-1PTB結構域蛋白及其編碼序列和應用(第一發明人)

國際發明專利:

SH2 domain variants (PCT國際發明專利,中美加,第三發明人)

專業碩士招生專業:

1.化學工程專業

2.生物與醫藥專業

3.護理學

聯系方式:

地址:伟德首页官网302

Emailcaoxuanwhu@126.com


 

 

 

 

 

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