學術報告
報告名稱：New insights into immunometabolism
報告人：浙江大學伟德首页官网王迪教授
報告時間：2023年11月3日（星期五）下午3點10分—4點10分
報告地點：伟德首页官网437會議室
主持人：曹軒
報告主要内容：
Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the colonic host-microbe interactions that help maintain gut homeostasis. However, the precise intracellular machinery underlying this goblet cell-induced mucus secretion remains poorly understood. Gasdermin D (GSDMD) is a recently identified pore-forming effector protein that causes pyroptosis, a lytic proinflammatory type of cell death occurring during various pathophysiological conditions. Here, we reveal an unexpected function of GSDMD in goblet cell mucin secretion and mucus layer formation. Specific deletion of Gsdmd in intestinal epithelial cells (ΔIEC) led to abrogated mucus secretion with a concomitant loss of the mucus layer. This impaired colonic mucus layer in GsdmdΔIEC mice featured a disturbed host-microbial interface and inefficient clearance of enteric pathogens from the mucosal surface. This study links epithelial GSDMD to the secretory granule exocytotic pathway and highlights its physiological nonpyroptotic role in shaping mucosal homeostasis in the gut.
王迪教授簡介：
王迪，浙江大學求是特聘教授，浙江大學伟德首页官网副院長（分管研究生工作），感染與免疫研究中心主任。作為最後通訊作者在Immunity (2016, 2018)，Science Immunology，Cell Metabolism，Molecular Cell (2019, 2020)，Developmental Cell，Nature Communications等國際權威學術雜志上發表多篇學術論文。獲得國家傑出青年基金、優秀青年基金資助，入選教育部“青年長江學者”、浙江省“萬人計劃”科技創新領軍人才、浙江省有突出貢獻青年科技人才，榮獲浙江省優秀博士論文導師 (2018, 2021)，藥明康德生命化學研究學者獎，樹蘭醫學青年獎等。
碩士學位點申報指導：
2023年11月3日（星期五）下午4點15分—5點15分，臨床醫學、護理學2個專碩點，伟德首页官网305會議室
